Looking Beyond the ASUS Prime Threadripper TR4 E-ATX Motherboard? 6 Alternatives Worth a Look
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The ASUS Prime X399-A TR4 E-ATX motherboard supports AMD Threadripper processors with up to 128GB of DDR4 memory. If you are looking for asus prime x399 a amd threadripper alternatives, this list covers seven other boards. These options share key specifications like the E-ATX form factor or TR4/SP5 sockets. They also overlap in features such as extensive M.2 slots or high-speed networking.
Some buyers may prefer modern DDR5 support or newer Wi-Fi standards. Others might need a smaller ATX layout or a different brand. This guide highlights alternatives that match the original’s build quality and connectivity. You can choose based on your specific CPU socket or memory requirements. Each selection offers distinct advantages for workstations or high-end gaming rigs.
Our top pick: ASUS Prime Threadripper TR4 E-ATX Motherboard.
Comparing alternatives to the ASUS Prime X399-A
ASUS ROG Maximus Z690 E-ATX Motherboard
The ASUS ROG Maximus Z690 uses the Intel LGA 1700 socket and Z690 chipset, making it incompatible with your Threadripper CPU. It supports DDR5 memory and PCIe 5.0 storage, offering significantly faster data transfer rates than the original’s DDR4 and PCIe 3.0 limits. You gain Wi-Fi 6E and 2.5GbE networking for modern connectivity needs. This board is larger, measuring 12 by 10.9 inches, and weighs 2.2 pounds. It is designed for high-end gaming builds rather than workstation tasks. If you are building with Intel 12th Gen processors and need high-speed storage and networking, this is a strong premium choice. It sacrifices Threadripper compatibility for modern Intel features and faster memory standards.
Gigabyte Dual Socket SP5 E-ATX Motherboard
The Gigabyte Dual Socket SP5 E-ATX motherboard is a specialized server board designed for dual EPYC CPUs. It weighs 7 pounds, making it much heavier than the original. This board is not suitable for standard desktop gaming or general home use. It offers out-of-band management features for server environments. You cannot use it with Threadripper processors. It is intended for users requiring dual EPYC CPUs and high availability. If you need a server platform with dual sockets, this is the right choice. It gives up desktop usability and Threadripper compatibility for enterprise-grade server features. The E-ATX form factor accommodates the dual-socket design. This board is a niche product for specific server builds rather than a general-purpose alternative.
MSI MEG X870E E-ATX Motherboard
The MSI MEG X870E E-ATX motherboard uses the AM5 socket and supports PCIe 5.0, which is incompatible with your TR4 CPU. It supports DDR5 memory for higher bandwidth. You get Wi-Fi 7 and extensive M.2 storage options. This board measures 14.1 by 10.5 inches and weighs 1 pound. It is larger than the original and designed for large chassis systems. It offers top-tier networking and maximum power delivery for modern AMD Ryzen processors. If you need the latest connectivity standards and high-speed storage, this is a strong option. It sacrifices Threadripper compatibility for AM5 features. The board is ideal for builders who prioritize PCIe 5.0 and Wi-Fi 7 over older platform support.
ASUS ROG Crosshair X870E Glacial E-ATX Motherboard
The ASUS ROG Crosshair X870E Glacial uses the AM5 socket and DDR5 memory, making it incompatible with your Threadripper CPU. It features dual 10GbE LAN ports and Wi-Fi 7 for exceptional networking speed. The board includes an M.2x7 configuration and a 5-inch LCD display. It measures 12 by 10.9 inches and weighs 1.5 inches in height. This board is designed for AMD enthusiasts who need extensive M.2 storage and high-speed networking. It offers PCIe 5.0 support for faster data transfers. If you require dual 10Gb networking and modern AMD features, this is a strong choice. It gives up Threadripper compatibility for AM5 advantages. The board is ideal for users who prioritize networking and storage over workstation CPU support.
Gigabyte TRX50 AERO D with Ryzen Threadripper 9960X
The Gigabyte TRX50 AERO D with Ryzen Threadripper 9960X is a high-core-count workstation solution. It supports the newer Threadripper 9000 series, not the original TR4 CPU. It uses DDR5 memory and PCIe 5.0 for faster performance. You get Wi-Fi 7 and 10GbE networking. This board is designed for high-core-count workstation builds. It prioritizes processing power and modern connectivity standards over compact form factors. If you need the latest Threadripper processors and high-speed networking, this is the right choice. It sacrifices TR4 compatibility for newer CPU support. The board is ideal for users who prioritize processing power and modern connectivity. It is a specialized solution for high-end workstation tasks rather than a direct alternative for older CPUs.
MSI MPG X570 Gaming Edge ATX Motherboard
The MSI MPG X570 Gaming Edge ATX motherboard uses the AM4 socket and supports PCIe 4.0, making it incompatible with your Threadripper CPU. It supports DDR4 memory, similar to the original. You get Wi-Fi 5 for wireless connectivity. The board measures 12 by 9.6 inches and weighs 4.1 pounds. It is an ATX form factor, smaller than the original E-ATX. This board is designed for AM4 gaming builds. It balances essential features like PCIe 4.0 and Wi-Fi 5 in a manageable layout. If you are building with AM4 processors and need a mid-range gaming option, this is a solid choice. It gives up Threadripper compatibility for AM4 features. The board is ideal for gamers who prioritize value and compact size over high-end workstation specs.
Quick picks
Our 7 picks
ASUS Prime Threadripper TR4 E-ATX Motherboard
Best for: Threadripper TR4 workstation builds
- CPU Socket
- TR4
- Chipset
- X399
- Form Factor
- Extended ATX
- Memory Type
- DDR4
- Series
- Ryzen Threadripper
- Dimensions
- 12 × 1 × 10.1 inches
View on Amazon: ASUS Prime Threadripper TR4 E-ATX Motherboard Affiliate link
This is an Extended ATX motherboard built for AMD Ryzen Threadripper TR4 processors. It supports up to 128GB of DDR4 memory and includes dual NVMe M.2 slots. The board features a U.2 port and USB 3.1 Gen2 connectivity. It uses the X399 chipset for high-end desktop tasks. You will find it suitable for workstation builds requiring extensive memory and storage options.
Pros
- Supports up to 128GB of DDR4 memory
- Includes dual NVMe M.2 drives and a U.2 port
- Features USB 3.1 Gen2 connectivity
- Uses the X399 chipset for Threadripper TR4
Cons
- Uses older DDR4 memory instead of DDR5
- No mention of Wi-Fi or Bluetooth connectivity
- Limited to TR4 socket, not compatible with newer CPUs
Good fit if
- You need a platform for AMD Threadripper TR4 processors
- You require support for up to 128GB of RAM
- You want dual M.2 slots and U.2 connectivity
Skip if
- You are building with Intel or newer AMD sockets
- You require DDR5 memory support
- You need integrated Wi-Fi or Bluetooth
Verdict: ASUS Prime X399-A E-ATX is a solid choice for users building with AMD Threadripper TR4 processors who need extensive memory and storage options. It fits those prioritizing DDR4 capacity and U.2 connectivity over modern wireless features.
ASUS ROG Maximus Z690 E-ATX Motherboard
Best for: high-end Intel 12th Gen gaming builds
- CPU Socket
- LGA 1700
- Chipset
- Z690
- Form Factor
- Extended ATX
- Memory Type
- DDR5
- PCIe Version
- PCIe 5.0
- M.2 Slots
- 5
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The ASUS ROG Maximus Z690 Extreme is an E-ATX gaming motherboard for Intel 12th Gen processors. It features a 24+1 power stage design rated for 105 A and supports DDR5 memory. You get five M.2 slots and PCIe 5.0 connectivity. Networking includes Wi-Fi 6E and a 10Gb Ethernet port. This board suits users needing robust power delivery and high-speed storage options.
Pros
- 24+1 power stages rated for 105 A
- Supports DDR5 memory and PCIe 5.0
- Five M.2 slots for storage expansion
- Onboard Wi-Fi 6E and 10Gb Ethernet
Cons
- E-ATX form factor requires a large case
- Limited to 64 GB maximum RAM capacity
- No mention of USB4 or Thunderbolt support
Good fit if
- You are building a high-end Intel gaming PC
- You need extensive M.2 storage options
- You require 10Gb Ethernet connectivity
Skip if
- You are using an AMD Ryzen processor
- Your case only supports ATX or smaller boards
- You need more than 64 GB of RAM
Verdict: ASUS ROG Maximus Z690 Extreme E-ATX delivers robust power and connectivity for Intel 12th Gen builds. It fits enthusiasts who prioritize high-speed storage and networking in a large chassis.
Gigabyte Dual Socket SP5 E-ATX Motherboard
Best for: dual EPYC server builds
- CPU Socket
- Socket SP5
- Form Factor
- Extended ATX
- M.2 Slots
- 1
- Weight
- 9 pounds
View on Amazon: Gigabyte Dual Socket SP5 E-ATX Motherboard Affiliate link
This Gigabyte motherboard supports dual AMD EPYC 9004 Series processors via Socket SP5. It uses 5nm technology and offers a single M.2 slot with PCIe Gen4 x4 connectivity. The board includes a dedicated management port and weighs 7 pounds. It is designed for high-density server environments rather than consumer desktops.
Pros
- Supports dual AMD EPYC 9004 Series CPUs
- Includes a dedicated management port
- Features PCIe Gen4 M.2 connectivity
- Built on 5nm technology
Cons
- Only one M.2 slot available
- Heavy 7-pound build
- Limited to PCIe Gen4 speeds
Good fit if
- You need dual EPYC processor support
- You require a dedicated management port
- You are building a server rack
Skip if
- You need multiple M.2 slots
- You are building a consumer desktop
- You want PCIe Gen5 support
Verdict: Gigabyte MZ73-LM0 SP5 E-ATX is a specialized server board for users requiring dual EPYC CPUs and out-of-band management. It is not suitable for standard desktop gaming or general home use.
MSI MEG X870E E-ATX Motherboard
Best for: builders needing maximum M.2 and networking specs
- CPU Socket
- AM5
- Chipset
- AMD X870E
- Form Factor
- E-ATX
- Memory Type
- DDR5
- PCIe Version
- PCIe 5.0
- M.2 Slots
- 5
View on Amazon: MSI MEG X870E E-ATX Motherboard Affiliate link
The MSI MEG X870E Godlike Max is an E-ATX motherboard built for AMD AM5 processors. It features a 24-phase power design and supports DDR5 memory up to 9200 MT/s. You get seven M.2 slots, including two PCIe 5.0 options, plus Wi-Fi 7 and 10Gbps LAN. This board suits builders who need maximum storage and high-speed networking for workstation or high-end gaming tasks.
Pros
- 24-phase power delivery for stable CPU performance
- Seven M.2 slots with dual PCIe 5.0 support
- Integrated 3.99-inch LCD dashboard for monitoring
- Wi-Fi 7 and 10Gbps Ethernet connectivity
- USB4 Type-C port with display output
Cons
- E-ATX form factor requires a large case
- 1-pound weight adds bulk to the build
- No mention of built-in video outputs for CPU
Good fit if
- You need extensive PCIe 5.0 storage expansion
- You want Wi-Fi 7 and 10Gbps networking
- You prefer hardware monitoring via an LCD panel
Skip if
- You are building in a standard ATX case
- You only need basic connectivity for office work
- You prefer a lighter, more compact motherboard
Verdict: The MSI MEG X870E Godlike Max E-ATX fits users who require extensive M.2 storage and top-tier networking. It is ideal for those building large chassis systems that demand maximum power and connectivity.
ASUS ROG Crosshair X870E Glacial E-ATX Motherboard
Best for: Users requiring dual 10Gb networking
- CPU Socket
- AM5
- Chipset
- X870E
- Form Factor
- E-ATX
- Memory Type
- DDR5
- PCIe Version
- PCIe 5.0
- M.2 Slots
- 7
View on Amazon: ASUS ROG Crosshair X870E Glacial E-ATX Motherboard Affiliate link
This E-ATX motherboard targets high-end AMD Ryzen 9000, 8000, and 7000 series processors via the AM5 socket. It stands out with dual 10Gb LAN ports and Wi-Fi 7 support. The board features seven M.2 slots and PCIe 5.0 connectivity. You get a robust 24+2+2 power stage design and a 5-inch LCD screen. It suits users needing serious network throughput and storage expansion.
Pros
- Dual 10Gb Ethernet LAN ports
- Wi-Fi 7 connectivity
- Seven M.2 slots for storage
- PCIe 5.0 support
- 24+2+2 power stage configuration
Cons
- E-ATX form factor requires a large case
- No mention of USB-C front panel header
- Higher cost than standard ATX boards
Good fit if
- You need dual 10Gb networking
- You use AMD Ryzen 9000 series CPUs
- You want seven M.2 storage slots
Skip if
- You use Intel processors
- You have a small form factor case
- You only need standard Gigabit Ethernet
Verdict: The ASUS ROG Crosshair X870E Glacial delivers exceptional connectivity with dual 10Gb LAN and Wi-Fi 7. It is the right choice for AMD enthusiasts who need extensive M.2 storage and high-speed networking.
Gigabyte TRX50 AERO D with Ryzen Threadripper 9960X
Best for: High-core workstation builds requiring PCIe 5.0
- CPU Socket
- sTR5
- Form Factor
- E-ATX
- Memory Type
- DDR5
- PCIe Version
- PCIe 5.0
- Wi-Fi Standard
- Wi-Fi 7
- Ethernet Speed
- 10GbE + 2.5GbE
View on Amazon: Gigabyte TRX50 AERO D with Ryzen Threadripper 9960X Affiliate link
This bundle pairs the 24-core AMD Ryzen Threadripper 9960X with the Gigabyte TRX50 AERO D sTR5 motherboard. The E-ATX board features a 16+8+4 phase VRM design and supports DDR5 memory up to 1TB. You get PCIe 5.0 connectivity, Wi-Fi 7, and dual USB4 ports. It is built for users needing high core counts and fast data transfer speeds for workstation tasks.
Pros
- 24-core, 48-thread AMD Ryzen Threadripper 9960X CPU
- Gigabyte TRX50 AERO D with 16+8+4 phase VRM
- Supports up to 1TB of DDR5 memory
- Wi-Fi 7 and dual 10GbE + 2.5GbE LAN
- Three PCIe 5.0 x4 M.2 slots
Cons
- E-ATX form factor requires a large case
- CPU cooler not included in the bundle
- Discrete graphics card required for display output
Good fit if
- You need 24 cores for heavy rendering or simulation
- You want PCIe 5.0 storage speeds
- You require 10GbE networking for file transfers
Skip if
- You only have space for ATX or smaller boards
- You need integrated graphics for basic tasks
- You prefer a smaller sAM4 or AM5 platform
Verdict: Micro Center Threadripper 9960X + Gigabyte TRX50 AERO D is a high-core-count workstation solution for users who prioritize processing power and modern connectivity standards over compact form factors.
MSI MPG X570 Gaming Edge ATX Motherboard
Best for: AM4 gaming builds needing Wi-Fi 5
- CPU Socket
- AM4
- Chipset
- X570
- Form Factor
- ATX
- Memory Type
- DDR4
- PCIe Version
- PCIe 4.0
- Wi-Fi
- Wi-Fi 5
View on Amazon: MSI MPG X570 Gaming Edge ATX Motherboard Affiliate link
The MSI MPG X570 Gaming Edge WiFi uses the AMD X570 chipset for AM4 processors. It supports DDR4 memory and PCIe 4.0 speeds. On-board Wi-Fi 5 helps with connectivity. Audio Boost 4 and Nahimic 3 enhance sound quality. This ATX board suits gamers who need reliable performance and modern storage options without the bulk of E-ATX designs.
Pros
- Supports 2nd and 3rd Gen AMD Ryzen desktop processors
- On-board Wi-Fi 5 with MU-MIMO support
- PCIe 4.0 bandwidth for faster data transfer
- Audio Boost 4 technology with Nahimic 3 software
Cons
- Uses older Wi-Fi 5 instead of Wi-Fi 6E
- Limited to DDR4 memory rather than DDR5
- Standard ATX size lacks extra expansion slots of E-ATX
Good fit if
- You build a PC with an AM4 Ryzen processor
- You want solid Wi-Fi 5 connectivity for gaming
- You prefer a compact ATX form factor
Skip if
- You need the latest Wi-Fi 6E standard
- You plan to use DDR5 memory modules
- You require an E-ATX board for maximum expansion
Verdict: The MSI MPG X570 Gaming Edge WiFi AM4 ATX is a solid mid-range option for gamers using AM4 CPUs. It balances essential features like PCIe 4.0 and Wi-Fi 5 in a manageable ATX layout.
Specifications side by side
| Spec | ASUS Prime Threadripper TR4 E-ATX Motherboard | ASUS ROG Maximus Z690 E-ATX Motherboard | Gigabyte Dual Socket SP5 E-ATX Motherboard | MSI MEG X870E E-ATX Motherboard | ASUS ROG Crosshair X870E Glacial E-ATX Motherboard | Gigabyte TRX50 AERO D with Ryzen Threadripper 9960X | MSI MPG X570 Gaming Edge ATX Motherboard |
|---|---|---|---|---|---|---|---|
| CPU Socket | TR4 | LGA 1700 | Socket SP5 | AM5 | AM5 | sTR5 | AM4 |
| Chipset | X399 | Z690 | not stated | AMD X870E | X870E | not stated | X570 |
| Form Factor | Extended ATX | Extended ATX | Extended ATX | E-ATX | E-ATX | E-ATX | ATX |
| Memory Type | DDR4 | DDR5 | not stated | DDR5 | DDR5 | DDR5 | DDR4 |
| PCIe Version | not stated | PCIe 5.0 | not stated | PCIe 5.0 | PCIe 5.0 | PCIe 5.0 | PCIe 4.0 |
| M.2 Slots | not stated | 5 | 1 | 5 | 7 | not stated | not stated |
| Wi-Fi Standard | not stated | Wi-Fi 6E | not stated | Wi-Fi 7 | WiFi 7 | Wi-Fi 7 | not stated |
| Ethernet Speed | not stated | 10Gb, 2.5Gb | not stated | 10Gbps + 5Gbps | 2X 10Gb LAN | 10GbE + 2.5GbE | not stated |
| Power Phases | not stated | 24+1 | not stated | 24 | 24+2+2 | 16+8+4 | not stated |
| Wi-Fi | not stated | Wi-Fi 6E | not stated | Wi-Fi 7 | Wi-Fi 7 | Wi-Fi 7 | Wi-Fi 5 |
| Use Case | not stated | Gaming | not stated | not stated | not stated | not stated | Gaming |
| Series | Ryzen Threadripper | not stated | not stated | not stated | not stated | Ryzen Threadripper | not stated |
| Dimensions | 12 × 1 × 10.1 inches | 12 × 10.9 × 1.93 inches | not stated | 14.1 × 1.1 × 10.5 inches | 12 × 10.9 × 1.5 inches | not stated | 12 × 9.6 × 2.5 inches |
| Weight | 4.5 pounds | 2.2 pounds | 9 pounds | 1 pounds | not stated | not stated | 4.1 pounds |
| Size | Extended ATX | not stated | not stated | 12" x 10.9" | X870E Glacial|M.2x7|5”LCD | not stated | 1 |
| Model | PRIME X399-A | PRIME H610M-A D4-CSM | MZ73-LM0 | MEG X870E GODLIKE MAX | ROG CROSSHAIR X870E GLACIAL | 9960XTRX50AEROD | MSI MPG X570 Gaming Edge WiFi |
| Color | not stated | not stated | not stated | Information Not Available | SILVER | AMD THREADRIPPER 9960X+ GBT TRX50 Aero D sTR5 | not stated |
If you need a compatible power supply for your system, review the asus prime 750w gold power alternatives.
Frequently asked questions
Can I use these alternatives with my existing Threadripper TR4 processor?
Only the Gigabyte TRX50 AERO D and the original ASUS Prime X399-A support AMD Threadripper CPUs. The TRX50 board uses the newer sTR5 socket for Ryzen Threadripper 9000 series. All other options use different sockets like LGA 1700 or AM5, which are incompatible with your current hardware.
Which motherboard offers the best connectivity for high-speed networking?
The ASUS ROG Crosshair X870E Glacial provides dual 10Gb LAN ports and Wi-Fi 7. It also supports PCIe 5.0 and DDR5 memory. This board is ideal if you need extensive M.2 storage and top-tier networking speeds for demanding workloads or large file transfers.
Is there an option that supports DDR5 memory instead of DDR4?
Yes, several alternatives support DDR5. The ASUS ROG Maximus Z690, MSI MEG X870E, ASUS ROG Crosshair X870E Glacial, and Gigabyte TRX50 AERO D all use DDR5. These boards offer faster memory speeds compared to the DDR4 support found in the original ASUS Prime X399-A.
What is the largest form factor available in this list?
The MSI MEG X870E Godlike Max measures 14.1 inches in length and 10.5 inches in height. This E-ATX size is larger than the standard 12-inch length found in most other options. You will need a large chassis to accommodate this specific board.
Which board is best for dual processor server builds?
The Gigabyte Dual Socket SP5 E-ATX Motherboard is designed for dual EPYC server builds. It supports out-of-band management features. This specialized board is not suitable for standard desktop gaming or general home use, focusing instead on high-density server environments.
Does any alternative include Wi-Fi 7 for wireless connectivity?
Three boards include Wi-Fi 7: the MSI MEG X870E, ASUS ROG Crosshair X870E Glacial, and Gigabyte TRX50 AERO D. The ASUS ROG Maximus Z690 offers Wi-Fi 6E. These options provide modern wireless standards for faster and more reliable connections.
Are there any ATX-sized options instead of E-ATX?
The MSI MPG X570 Gaming Edge is an ATX motherboard, measuring 12 inches by 9.6 inches. It is smaller than the E-ATX boards listed. This board supports AM4 CPUs and PCIe 4.0, making it a compact choice for mid-sized cases.